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Functional Genomics and Complex System Lab (FG&CSL) - Research on Medicinal Entomopathogenic Fungi

Samsoniellahepiali

Pioneering research in medicinal entomopathogenic fungi at CSIR-IHBT

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Samsoniella hepiali
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Samsoniella hepiali

An entomopathogenic fungus with significant medicinal potential

Entomopathogenic
Himalayan Origin

Species Overview

Scientific Classification
Kingdom: Fungi
Division: Ascomycota
Class: Sordariomycetes
Order: Hypocreales
Family: Cordycipitaceae
Genus: Samsoniella
Species: S. hepiali

Samsoniella hepiali is a remarkable entomopathogenic fungus belonging to the family Cordycipitaceae. This fungus is known for its unique ability to parasitize insects, particularly larvae of Hepialus moths, and has gained significant attention for its medicinal properties.

The fungus produces various bioactive compounds with potential therapeutic applications, including immunomodulatory, anti-inflammatory, and antioxidant effects. Our research at FGCSL focuses on understanding its genetic basis, metabolic pathways, and pharmacological potential.

Samsoniella hepiali specimen
Microscopic View
First Described: 1970s
Temperature: 15-25°C
Host: Hepialus larvae

Morphological Characteristics

Structural features and identification markers

Macroscopic Features

  • Stromata cylindrical to clavate
  • Yellowish to orange-brown coloration
  • Length: 2-8 cm
  • Diameter: 2-5 mm
  • Smooth to slightly rough surface

Microscopic Features

  • Asci cylindrical, 200-400 × 4-6 μm
  • Ascospores filiform, multiseptate
  • Phialides flask-shaped
  • Conidia ellipsoidal to cylindrical
  • Cultural characteristics on PDA

Habitat & Distribution

Geographical range and ecological preferences

Geographical Range

Himalayan Region Distribution

Primary Regions: Eastern Himalayas, Tibetan Plateau
Altitude Range: 2000 - 4000 meters
Countries: India, China, Nepal, Bhutan

Ecological Characteristics

Climate

Alpine and sub-alpine regions with cold, humid conditions

Vegetation

Rhododendron forests, alpine meadows, mossy substrates

Host Specificity

Primarily parasitizes Hepialidae larvae in soil and litter

Bioactive Compounds

Key chemical constituents with medicinal properties

Cordycepin

A nucleoside analogue with broad-spectrum biological activities including:

  • Anti-inflammatory effects
  • Immunomodulatory properties
  • Anti-cancer potential
  • Antiviral activity
Polysaccharides

Complex carbohydrates with significant medicinal value:

  • Immune system enhancement
  • Antioxidant properties
  • Anti-fatigue effects
  • Hepatoprotective activity
Other Metabolites

Additional bioactive compounds identified:

  • Ergosterol and derivatives
  • Nucleosides (adenosine, guanosine)
  • Peptides and amino acids
  • Enzymes (proteases, chitinases)

Medical Applications

Traditional uses and modern therapeutic potential

Traditional Medicine

In traditional Chinese and Tibetan medicine, Samsoniella hepiali has been used for centuries to:

Treat respiratory disorders
Enhance physical endurance
Improve cardiovascular health
Boost cognitive function

Modern Research

Current scientific research has validated several therapeutic applications:

Immunomodulation

Enhances immune response and regulates immune system

Antioxidant Activity

Reduces oxidative stress and protects cells

Anti-inflammatory

Reduces inflammation through multiple pathways

Explore Our Research Database

Access comprehensive data on Samsoniella hepiali including genomic sequences, chemical profiles, and research findings.

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